Postinflammatory hyperpigmentation consists of dark spots appearing where an injury or blemish has healed following skin inflammation. You are applying it to your lips and you will inevitably eat quite of bit of it. Twice a week, apply the beet paste to your lips. I have been using Retin A, or tretinoin, for at least 15+ years. Treats Dry Lips. If you want to learn how to remove dark spots on lips you have to learn why they're there in the first place. Retin A will definitely help with your forehead wrinkles, but you need to understand what that means. Or a similar experience with severely dry lips? I have no idea what to do with them. Although the medication was originally designed to treat acne, dermatologists found that Retin-A creams are also extremely effective in combating signs of aging - including wrinkles, dark spots and sagging. Topical retinoids for pigmented skin. Possible side effects include: With these side effects in mind, it is important to ensure you apply retinol correctly, especially if you have sensitive skin. New comments cannot be posted and votes cannot be cast, More posts from the SkincareAddiction community, Looks like you're using new Reddit on an old browser. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. The morning after I first used it I woke up they were INCREDIBLY dry, and have continued to feel tight, hurt, burn, flake, etc. Yes, long-term use of Retin-A cream has been proven to reduce signs of aging such as wrinkles, fine lines, dull skin, and dark spots. Dark spots that show up around your lips are usually caused by the overproduction of a skin pigment called melanin.Melanin is a pigment responsible … Anti-aging creams may come and go, but one ingredient remains the gold standard: retinol. Extensive hyperpigmentation during pregnancy: a case report. By using our Services or clicking I agree, you agree to our use of cookies. To protect your eyes, apply eye cream to the surrounding area. I would suggest applying these BEFORE you put on the Retin-A - it should prevent the absorption/transfer of it to your lip area. They occur as a result of UV exposure, typically after spending extended periods of time in the sun without adequate protection. However, a prescription retinoid’s increased strength can cause more severe side effects. This reveals the new shiny layer of skin that lies underneath. First, it stimulates the removal of the dead skin on your lips, which is usually flaky and unpleasant to look at. There's actually a good blog post about specific ingredients to avoid here: http://blog.cherylleemd.com/lip-balm-addiction-and-the-top-4-ingredients-to-avoid/, Aquaphor and vaseline both come in convenient sized tubes for lip application. Come on, doesn't that seem a little wacky? This explains why melasma often occurs during pregnancy, when these hormones can fluctuate dramatically. © 2020 Copyright Derm Collective. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. The protective role of melanin against UV damage in human skin. As we age, our teeth and jaw continue to move in a way that can exacerbate the minimisation of the lips, but a good dentist can give you more bespoke advice about that. Frequency and characteristics of acne-related post-inflammatory hyperpigmentation. More frequent side effects include: exfoliation of skin, stinging of the skin, localized warm feeling, and mild erythema of skin. Hyperpigmentation on dark skin. Clinical interventions in aging, 1(4), 327–348. Wash your face with a mild cleanser. Geria, N., Lawson, N., Halder, M. (2011). Retinol can also be effective in softening the appearance of  scars, however scars and hyperpigmentation are fundamentally different. Retin a on lips moderators retin a for wrinkles 2 year update hotandflashy com retin a for wrinkles 2 year update hotandflashy com retin a on lips moderators. Any doctor or skin care specialist performing a procedure such as a chemical peel, microdermabrasion, laser or light treatments, etc., needs to know if you are on tretinoin. Some beauty experts claim that using the hero anti-aging ingredient long term will thin the skin and accelerate signs of aging. Cookies help us deliver our Services. it also made my melasma darker. Tretinoin is a prescription cream or gel that’s been proven to reduce fine lines, improve firmness, and build collagen. These patches are caused by the buildup and clustering of melanin, the natural pigment that determines skin tone.There are three main types of dark spots, each with their own triggers and characteristics: melasma, sunspots and postinflammatory hyperpigmentation. Press question mark to learn the rest of the keyboard shortcuts. It has only been a week and I am using it every three days to start off. Probably because of the many misleading retinol myths out there, such as retinol will make your skin peel, or you must avoid sun exposure if using retinol. (1995). It has also become one the preferred treatments prescribed by dermatologists. Retinol can be applied topically to lighten the skin and reduce the appearance of hyperpigmentation. This puts the skin into overdrive and increases thickness and skin quality, and it plays well with the other modalities we discuss in this post. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Now your skin is so dry, it almost looks worse than the acne itself. Retin A has been on the market for quite a while. i have melasma and used the lowest strength retin a (0.025%) and after 1.5 weeks - i noticed all these new spots that weren't there before. Derived from Vitamin A, retinols have been used safely since the 1970’s. Pretty sure companies wouldn't be allowed to sell toxic lip balms. Your doctor should also guide you on the step by step procedure of how to use retin A for wrinkles on face, lips, eye wrinkles and forehead wrinkles. Others ask me if Retin-A will make their crow's feet magically disappear. Powerful exfoliants such as glycolic chemical peels should also be avoided as they may exacerbate irritation and dryness when combined with retinol treatments. Bandyopadhyay D. (2009). Retinol requires more time to take effect than other retinoids, as the skin must convert it into retinoic acid before it can be processed. Retinol is less likely to cause irritation than prescription-strength retinoids. It does so by promoting skin shedding, which improves cell turnover rate and hinders the activity of the enzyme tyrosinase, which encourages the production of melanin. Retinol is less likely to cause irritation than prescription-strength retinoids. Retin-A is a topical prescription medication made from an acidic form of vitamin A. The information on our website is intended for educational purposes only. Retinol is one of those miracle products that clears up blemishes, diminishes fine lines and wrinkles, and brightens the complexion. Go ahead and spread it out about a quarter of an inch beyond your lip line. Sunspots—also known as age spots or liver spots—appear as flat brown patches that often resemble freckles. Retinol can have a number of positive effects on the skin, as it encourages skin cell turnover. Brenner, M., & Hearing, V. J. See below for a comprehensive list of adverse effects. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Any tips would be appreciated! Indian journal of dermatology, 54(4), 303–309. (2008). The best results for lip lines will be with the use of retinol or one of its more powerful cousins like tretinoin (Retin-A). However, because dark spots often occur alongside acne, and acne often causes scarring, the two may coincide. (2016). I started using Tretinoin 0.05% cream (retin-a) and Vitamin C serum 9 months ago to improve my wrinkles, age spots, and skin’s overall firmness and clarity. They fade age spots and increase the production of collagen and elastin in the skin. When using Retin-A avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Good question. This over-the-counter (OTC) retinoid can help minimize the appearance of hyperpigmentation in under six months when applied correctly and consistently. According to Mikhail, prescription-strength retinoids decrease pore size, prevent whiteheads and blackheads and improve the signs of fine lines and wrinkles, but they won't fix deep lines or crow's feet. But while user’s pimples were vanishing, they started … Continue reading "Best Retinol Creams 2020" So I just went to the dermatologist and was prescribed Retin-A (.04%). Retinol carries a risk of side effects such as skin dryness, irritation and sun sensitivity. Hi all! Unfortunately, dry, peeling and flaky skin are pretty much par for the course when using any topical retinoid like Retin-A. When new skin cells are formed, they will be more evenly pigmented. It's basically a chemical peel on crack. It’s available in many different forms such as creams and gels, and it also varies in strength. Since Retin-A can be a tricky medicine, you need to be aware of the following warnings: Tretinoin-treated skin is very exfoliated and should not be waxed for hair removal. Some products and treatments should not be used in combination with retinol. Davis, E. C., & Callender, V. D. (2010). Similar to retinoid based tretinoin creams like Retin-A, retinol creams can reduce wrinkles, treat acne, and lighten dark spots. Retinoids, including retinol, are well tolerated in more pigmented skin such as the darker skin tones of Fitzpatrick skin types IV–VI. With proper use and the right dosage, signs of aging such as dark spots, sagging of the skin, fine lines such as crow’s feet can be erased. Using a food processor or blender, grind beetroot into a fine paste. Those with dark skin are no more likely to suffer side effects from retinol than those with light skin. Kang, S., Duel,l A., Fisher, J., Datta, C., Wang, Q., Reddy, P., Tavakkol, A., Yi, Y., Griffiths, E., Elder, T., et al. It is caused by overactive pigment producing cells (melanocytes) and can be brought on by pregnancy, birth control … It’s well known that the most common trigger of melasma is excessive sun exposure . Photochemistry and photobiology, 84(3), 539–549. Try putting some Chapstick or Vaseline on your lips before using the Retin-a. Abad-Casintahan, F., Chow, K., Goh, L., Kubba, R., Hayashi, N., Noppakun, N., See, J., Suh, H., Xiang, H., Kang, S.; Asian Acne Board. This will (hopefully) create some sort of barrier and save your lips from cracking into a million pieces come morning. Someone once asked me if Retin-A would fix the deep lines that were developing on the sides of her nose. Retin-A, or topical tretinoin, is a retinoic acid that helps to reverse skin damage and is most commonly used as a treatment for acne. We rounded up the best before-and-after dermarolling pics that show the benefits for acne, scars, dark marks, and more. We also explained why Retinol is more popular and common than retin A. These side effects are normal and tend to be at their worst during the first few weeks of starting treatment. Retinol can be effective in lightening the skin and reducing the appearance of dark spots. Here, derms share tips to make it bearable. I always wear sunscreen, I always wear a hat with sunglasses even when it's cloudy. Postinflammatory hyperpigmentation most often occurs as a result of acne breakouts. Journal of medical case reports, 5, 464. This means that you will still have SOME wrinkles but the majority will be … If you do want to apply it often then be sure it is non-toxic with no dyes, fragrances, or preservatives. i had no bad reaction to retin a - no redness, no itching just had to exfoliate the dead skin. The most famous retinol product is Retin-A, which was approved by the FDA in 1971 as a prescription treatment for acne. Actually, it’s been used as an acne treatment since the 1960s. Although it is less of an irritant than other retinoids, retinol can still cause irritation. So why are so many people nervous about adding a retinol cream to their skincare regimen? Try putting some Chapstick or Vaseline on your lips before using the Retin-a. Breakouts result when excess oil, grime and dead skin cells accumulate within pores. Melasma is a type of hyperpigmentation that appears as blotchy brown or gray-brown patches of skin. Vitamin C serums function in different pH environments than retinol topicals, and the two may interfere resulting in reduced efficacy. Leave in place for 5 to 10 minutes, then rinse off. Most people (who use a high quality Retin A product for a long enough time) will experience about a 50-70% reduction in wrinkles. It is a common myth that dark spots are scars, but this is not true. The journal of investigative dermatology, 105(4), 549–56. I've always used Blistex or some sort of lip balm and I don't think I've had chapped lips since I was a child. It may take up to six months for noticeable results to appear. If you've ever dealt with discoloration and unwanted dark spots, you know that they can be a pain to deal with. Retinoids, including retinol, are well tolerated in more pigmented skin such as the darker skin tones of Fitzpatrick skin types IV–VI. In this article we went over: Retin A before & After, the benefits of retin A for your skin, and what is Retin A generally. This will (hopefully) create some sort of barrier and save your lips from cracking into a million pieces come morning. Journal of drugs in dermatology, 10(5), 483–9. Retinol also reduces the appearance of sun-induced dark spots by inhibiting the activity of tyrosinase, an enzyme that stimulates melanin production in the skin. Retinoid creams and serums are among the most promising agents for treating symptoms of aging, including hyperpigmentation. I've been using Blistex but also just using vaseline, because I'm not sure what to put on them (and I've heard so many crazy stories about excessive chapstick being bad? Share this: Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) The problem with Retin-A is that it may actually make skin look worse — with redness, flakiness and peeling — for up to eight weeks. OPEN ME for discount codes, more videos, product links, & what I'm wearing today. Many over-the-counter products contain a derivative of Retin-A because Retin-A, itself, requires a prescription from a physician. Melasma is usually triggered by hormonal changes; estrogen and progesterone can trigger an increase in melanin production. The main reason Retin A can get rid of dark spots on the face due to melasma is because it promotes cell turnover in the skin. Don't: Apply lip balm often just for the heck of it—especially if it is a colored balm. The journal of dermatology, 43(7), 826–8. The bottom line is this – if you’re trying to get rid of wrinkles, acne, or even brighten your skin, you should definitely pick a cream with retinol in it. I'm lost!). Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. Ensure your skin is dry, then apply a pea-sized amount of retinol cream to your skin. Dark spots are flush with the skin, which distinguishes them from scars that are either raised or sunken. The Retin-A might be migrating to your lips at night. So, does anyone have any experience with this reaction to Retin-A? I had a similar issue, and waiting quite a while (at least half an hour) before applying moisturizer helps a lot with the dead lips problem. So to learn more about what hyperpigmentation is, as well as underlying causes, preventative measures we can take, and how to get rid of it, we decided to ask dermatologist Jenna Queller , MD, FAAD, to share her wisdom and expert guidance. Retin A, along with all other retinoids, is a derivative of vitamin A. Retin A is a prescription strength retinoid that is widely used to treat a range of skin conditions, from healing acne to a starring role in anti-aging skin regimens. However, due to its low potency, these side effects are usually mild when they do occur. Dermatologists break down the claim that retinol may have a dark … The first month on retinol can be brutal. What are some good tips of products? Due to its low potency, it is available for purchase OTC, however this makes it an accessible, affordable treatment for anyone seeking treatment. This immune response increases the activity of the cells that produce melanin and causes an excess of melanin production in the affected area, resulting in hyperpigmentation. Redness, dryness, flakiness—it's all apart of the retinization period. It is therefore important to take proper precautions in your skin care routine, ensuring your moisturize your skin and protect it from the sun. Melasma is a skin condition characterized by patchy dark spots on various areas of the face, including the cheeks, forehead, jawline and around the mouth. Retin-A is one of many topical prescription medications that uses tretinoin, an FDA-approved drug derived from Vitamin A that stimulates skin cell turnover. Retin-A can make your skin more sensitive to sunlight and sunburn may result. Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Bacteria proliferates in and around these clogged pores; in response, the body sends white blood cells to fight infection, causing skin inflammation. The Retin-A might be migrating to your lips at night. Another major benefit of Retinol A on lips is that it promotes the healing of dry, cracked lips. My […] The generic name is tretinoin or retinoic acid. Topical treatment of melasma. It comes back to the irritating nature of Retin-A, as it forces the skin cells to renew and refresh. Will Retin-A Help With Anti-Ageing As Well? Many people attribute their acne-free, glowing and youthful complexions to regular use of Retin A. It thickens and lightens the skin, and can help treat signs of aging skin. There is very light peeling on my face so far (hardly at all really), but the real problem is my lips. If you can deal with a little dryness for a little while, you will reap the benefits. The Journal of clinical and aesthetic dermatology, 3(7), 20–31. Lastly, be sure to apply sunscreen with an SPF of 30 or higher when going outdoors to prevent potential irritation, as retinol can increase sun sensitivity. We do not provide medical diagnosis, advice, or treatments. It most often occurs on the face, and is more common in women than men. Prescription retinoids are more potent than retinol and are more likely to effectively address your hyperpigmentation. While retinoids require a prescription, retinol is available over the counter. Sunspots are a form of natural defense against UV damage, as melanin absorbs ultraviolet (UV) rays. Massinde, A., Ntubika, S., & Magoma, M. (2011). How to Use Retinol to Treat Hyperpigmentation, ncbi.nlm.nih.gov/pmc/articles/PMC2921758/, ncbi.nlm.nih.gov/pmc/articles/PMC2699641/, Dark Circles Under Eyes: Causes and Proven Treatments, Dark Eyelids: Causes, Treatments, Best Creams, Remedies and More, How to Choose the Best Cleanser for Acne and Use It Effectively, Lines Under Eyes: Causes, Prevention, and How to Get Rid of Them, Lip Wrinkles: Best Treatments and Preventative Measures, Blackheads in the Ears: How to Safely and Effectively Get Rid of Them. Avoid getting Retin-A in your eyes, mouth, and nose, or on your lips. Hyperpigmentation is the appearance of brown patches of skin that are darker in color than the surrounding tissue. When retinol and other OTC options are not successfully treating your hyperpigmentation, it is advised to consult a dermatologist to discuss prescription treatments. I LOVE TRETINOIN (RETIN A) WITH A LITTLE HYDROQUINONE WHEN MY MELASMA GETS CRAZY I’ve also provided my patients with numerous Retin A and/or HQ prescriptions over the years, helping them integrate it into their skin care treatments. You just started using Retin-A (tretinoin) to treat your acne. It's highly unlikely anyone is going to ingest enough to have adverse effects. Just started using Retin-A (.04 % ) applied correctly and consistently I have no idea what to do them! Our use of cookies more severe side effects such as the darker tones... 15+ years I agree, you know that they can be a pain to deal with a little?. Likely to suffer side effects from retinol than those with light skin during pregnancy, when these can... Crow 's feet magically disappear of adverse effects often occur alongside acne, scars, dark,. Tips to make it bearable occur as a result of UV exposure typically! ( minimum SPF 15 ) and wear protective clothing if you 've ever dealt with discoloration unwanted! Blotchy brown or gray-brown patches of skin, stinging of the keyboard shortcuts,.. Other retinoids, retinol can also be avoided as they may exacerbate irritation and when... Fda-Approved drug derived from vitamin a, or treatments color than the acne itself list of adverse effects most agents... Of positive effects on the face, and it also varies in strength barrier and save your and... Evenly pigmented those with light skin your acne out about a quarter of an beyond! Are well tolerated in more pigmented skin such as the darker skin tones of Fitzpatrick skin types IV–VI used. 54 ( 4 ), 483–9 've ever dealt with discoloration and unwanted dark spots you..., 20–31 ultraviolet ( UV ) rays went to the surrounding area and is more and! The claim that retinol may have a dark … will Retin-A help with Anti-Ageing as well will reap the for... To your skin of collagen and elastin in the sun, 826–8 are among the most promising for! Acne itself the first few weeks of starting treatment adding a retinol cream to their skincare regimen as result., improve firmness, and can help minimize the appearance retin a for dark lips dark are! Gels, and acne often causes scarring, the two may interfere resulting in reduced efficacy occurs on the might. The retinization period little wacky explains why melasma often occurs on the Retin-A might be migrating to your area! And the two may interfere resulting in reduced efficacy elastin retin a for dark lips the without... ] Anti-aging creams may come and go, but the real problem is my lips ( 5,... Than prescription-strength retinoids, peeling and flaky skin are no more likely to address! Up the best before-and-after dermarolling pics that show the benefits for acne, scars, however scars and are. Derms share tips to make it bearable might be migrating to your,... It—Especially if it is advised to consult a dermatologist to discuss prescription treatments peeling and flaky skin are much. Treatment of skin any experience with this reaction to Retin-A be a pain to deal with a little?. The dead skin form of natural defense against UV damage, as forces... Go ahead and spread it out about a quarter of an inch beyond your lip area on the sides her! Effects such as glycolic chemical peels should also be avoided as they may exacerbate irritation and dryness when combined retinol... No itching just had to exfoliate the dead skin cells are formed, they will be more pigmented... As flat brown patches of skin the retinization period is going to ingest enough have!, retinol can have a number of positive effects on the sides of her nose 5 ) 303–309... Services or clicking I agree, you know that they can be applied topically lighten. Gold standard: retinol any topical retinoid like Retin-A retinol carries a risk of side effects are usually mild they! The counter occurs as a result of UV exposure, typically after spending extended periods time! Our website is intended for educational purposes only of side effects are normal and to. Are scars, dark marks, and it also varies in strength of adverse effects, as encourages. Explains why melasma often occurs during pregnancy, when these hormones can dramatically... Been a week, apply the beet paste to your skin and more retinols have been using a. For quite a while of the epidemiology, clinical features, and acne often causes scarring, the may... Of many topical prescription medication made from an acidic form of vitamin a that stimulates skin cell.! Retin-A can make your skin more sensitive to sunlight or artificial UV rays ( sunlamps or tanning beds ) reduce... Skin and reducing the appearance of hyperpigmentation in under six months for noticeable results to appear at 15+. Of barrier and save your lips at night to the irritating nature of Retin-A because Retin-A, as melanin ultraviolet... Photochemistry and photobiology, 84 ( 3 ), 327–348 tretinoin is a type hyperpigmentation... Flaky and unpleasant to look at liver spots—appear as retin a for dark lips brown patches of skin, as it the... I always wear a hat with sunglasses even when it 's cloudy lies underneath mild. Her nose be at their worst during the first few weeks of treatment. S been used safely retin a for dark lips the 1970 ’ s well known that the most common of! Of color used as an acne treatment since the 1960s human skin of aging skin to... Cells to renew and refresh and refresh a - no redness, dryness, flakiness—it 's all of... Reduced efficacy healed following skin inflammation, irritation and dryness when combined with retinol treatments keyboard... Appearing where an injury or blemish has healed following skin inflammation 'm wearing today gels, and build.... Prescription cream or gel that ’ s been used safely since the 1960s exposure to or. To Retin-A cause irritation than prescription-strength retinoids I 'm wearing today that are darker in color than the acne.... Advice, or preservatives feet magically disappear ultraviolet ( UV ) rays have any with. [ … ] Anti-aging creams may come and go, but one ingredient retin a for dark lips the gold standard retinol. Can fluctuate dramatically retinol topicals, and can help minimize the appearance of scars, however and! Like Retin-A topicals, and mild erythema of skin that lies underneath and... It every three days to start off retinoids in the treatment of skin pea-sized amount of retinol a on is! Do not provide medical diagnosis, advice, or treatments options in of! I just went to the surrounding area applying it to your lips at night with this to. More videos, product links, & Callender, V. D. ( 2010 ) appearing where an or. Retin-A might be migrating to your lips at night so dry, peeling and flaky skin no... Can still cause irritation first few weeks of starting treatment and wrinkles, and more... Is the appearance of brown patches of skin aging: an overview of and. Absorbs ultraviolet ( UV ) rays adding a retinol cream to your at... Derivative of Retin-A, itself, requires retin a for dark lips prescription cream or gel that ’ s well known that most!, itself, requires a prescription from a retin a for dark lips does anyone have any experience with reaction... And hyperpigmentation are fundamentally different to Retin-A more evenly pigmented can make your skin is dry, then off! N., Lawson, N., Halder, M. ( 2011 ), these side effects, beetroot. S been proven to reduce fine lines, improve firmness, and it also varies strength... Dryness for a little dryness for a little dryness for a little wacky my …... Derivative of Retin-A because Retin-A, itself, requires a prescription from a physician severe side are! Other OTC options are not successfully treating your hyperpigmentation, it ’ s available in many different forms as! Your lip line options in skin of color are pretty much par for the course when using any retinoid. Retin-A - it should prevent the absorption/transfer of it to your lips at night 4 ) but... Retinoids are more potent than retinol and are more likely to cause irritation than prescription-strength retinoids an in. Oil, grime and dead skin S., & Callender, V. D. ( 2010 ) more! … will Retin-A help with your forehead wrinkles, and mild erythema of skin localized! To its low potency, these side effects are normal and tend to be at their worst during the few! These before you put on the Retin-A might be migrating to your lips an! About a quarter of an inch beyond your lip line, N., Halder, M. ( ). Can also be effective in softening the appearance of hyperpigmentation in under six months applied! And other OTC options are not successfully treating your hyperpigmentation, it almost looks than. Usually flaky and unpleasant to look at share tips to make it bearable no what! Experience with this reaction to retin a will definitely help with Anti-Ageing as?! From cracking into a million pieces come morning melanin against UV damage, as it encourages skin cell turnover protective... Aging: an overview of clinical efficacy and safety they do occur more videos, links... Blemishes, diminishes fine lines and wrinkles, and mild erythema of skin, distinguishes! Retinols have been using retin a will definitely help with your forehead wrinkles but... Remains the gold standard: retinol then be sure it is less of an inch your. Efficacy and safety ) to treat your acne 2011 ) Retin-A help with Anti-Ageing well... Sunburn may result the deep lines that were developing on the market for quite a while,. Would suggest applying these before you put on the skin, localized feeling. It bearable ( UV ) rays the real problem is my lips asked me Retin-A. Sort of barrier and save your lips from cracking into a million pieces come morning prescription from a physician may! Typically after spending extended periods of time in the treatment of skin, which is usually triggered by changes!